SIGMA Members

The SIGMA Consortium is formed by a group of leading research institutions and universities with extensive expertise and experience in the conduct of pharmacoepidemiologic and real-world evidence research

Dr. Susana Perez-Gutthann, FISPE

SIGMA Executive Committee member, Board Chair

Spain/USA

RTI Health Solutions

HMA-EMA Catalogue Institution Registration Details

Prof. Ron Herings, FISPE

SIGMA Executive Committee member

Netherlands

PHARMO Institute for Drug Outcomes Research

HMA-EMA Catalogue Institution Registration Details

Prof. Vera Ehrenstein

SIGMA Executive Committee member

Denmark

Aarhus University Dept. of Clinical Epidemiology

HMA-EMA Catalogue Institution Registration Details

Dr. Rosa Gini

Italy

Agenzia Regionale di Sanità (ARS Toscana)

HMA-EMA Catalogue Institution Registration Details

Prof. Ulrike Haug

Germany

Leibniz-Institut für Präventionsforschung und Epidemiologie – BIPS GmbH

HMA-EMA Catalogue Institution Registration Details

Dr. Nicolas Thurin

France

University of Bordeaux’s Bordeaux PharmacoEpi Platform

HMA-EMA Catalogue Institution Registration Details

Prof. Isla Mackenzie

United Kingdom

University of Dundee

HMA-EMA Catalogue Institution Registration Details

Dr. Gabriel Sanfélix-Gimeno

SPAIN

FISABIO FOUNDATION

HMA-EMA Catalogue Institution Registration Details

Dr. Maria Giner-Soriano

Spain

Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol)

HMA-EMA Catalogue Institution Registration Details

Dr. Johan Reutfors

Sweden

Karolinska Institutet/Centre for Pharmacoepidemiology

HMA-EMA Catalogue Institution Registration Details

Dr. Øystein Karlstad

NORWAY

NIPH Dept. Chronic Diseases

HMA-EMA Catalogue Institution Registration Details

Prof. Jesper Hallas, FISPE

Denmark

University of Southern Denmark, Department of Clinical Pharmacology and Pharmacy

HMA-EMA Catalogue Institution Registration Details

Prof. Miriam Sturkenboom, FISPE

Netherlands

University Medical Centre Utrecht (UMCU)

HMA-EMA Catalogue Institution Registration Details

Prof. Olaf Klungel, FISPE

Netherlands

Utrecht University Division of Pharmacoepidemiology & Clinical Pharmacology

HMA-EMA Catalogue Institution Registration Details

The SIGMA consortium collaborates with the following research institutions and networks:

Prof. Giampiero Mazzaglia

Italy

UNIMIB

Dr. Gianluca Trifirò

Italy

University of Verona

Prof. Anna-Maija Tolppanen

FINLAND

University of Eastern Finland School of Pharmacy

VAccine monitoring Collaboration for Europe

Belgium

VAC4EU

EU PE & PV Research Network

Netherlands

EU PE & PV Network

Members and Collaborators of the SIGMA Consortium have extensive research experience and protocol-based access to data sources for the conduct of RWE/pharmacoepidemiology studies

Name of data source
Danish Health
Registers
Finnish Health
Registers
SNDS
GePaRD
ARS Toscana
Caserta Regional
Database
THIN
PHARMO Database
Network
Norwegian Health
and Administrative
Registers
SIDIAP
VID
Swedish Health Registers
Scottish Prescribing
Information System
CPRD
Country
Denmark
Finland
France
Germany
Italy
Italy
Italy
Netherlands
Norway
Spain
Spain
Sweden
UK
UK
Institution
Aarhus University | SDU
University of Eastern Finland
Bordeaux
PharmacoEpi
BIPS GmbH
ARS Toscana
University of
Verona
UNIMIB
PHARMO Institute
NIPH
IDIAP JGol
FISABIO
Karolinska
Institute
University of
Dundee
RTI Health Solutions | Ultretch University
Name of database Country
Type
Danish Health Registers
Linked registers for dispensed prescriptions, laboratory values, hospitalizations, and mortality
Finnish Health Registers
Linked national registers for dispensed prescriptions, hospitalisations and outpatient visits, laboratory values, mortality, causes of death​
SNDS
Claims
GePaRD
Claims from 4 SHI proveiders
ARS Toscana
Claims data
Caserta Regional Database
Claims
THIN
Primary health care electronic medical records
PHARMO Database Network
Primary health care electronic medical record + partial linkage to other dcata
Norwegian Health and Administrative Registers
Linked national registers for dispensed prescriptions, hospitalizations, specialist outpatient care, primary care, and causes of death
SIDIAP
Primary health care electronic medical records + partial linkage to other data
FISABIO
Primary care, specialist outpatient care, hospitalizations, emergency room visits, prescribed and dispensed prescriptions, laboratory test, causes of death
Swedish Health Registers
Linked national national refisters for dispensed prescriptions, hospitalizations, and mortality.
Scottish Prescribing Information System
Prescriptions linked to diagnoses
CPRD
Primary health care electronic medical records + partial linkage to other data
Name of database Country
Size
Danish Health Registers
5.8 million
Finnish Health Registers
5.5 million
SNDS
66 million
GePaRD
17.5 million
ARS Toscana
3.6 million
Caserta Regional Database
1.2 million
THIN
1.7 million full db
/ 860.000 active
patients
PHARMO Database Network
4 million
Norwegian Health and Administrative Registers
5.5 million
SIDIAP
5.6 million
FISABIO
5 million
Swedish Health Registers
10.5 million
Scottish Prescribing Information System
5.4 million
CPRD
 Aurum: 13.3 million GOLD: 2.9 million of acceptable patients
Name of database Country
(% coverage)
Danish Health Registers
(100% Denmark)
Finnish Health Registers
(100% Finland)
SNDS
(99% France)
GePaRD
(21% Germany)
ARS Toscana
(100% Tuscany region)
Caserta Regional Database
(21% Campania region)
THIN
(1,5% Italy)
PHARMO Database Network
(23% Netherlands)
Norwegian Health and Administrative Registers
(100% Norway)
SIDIAP
(73% Catalonia)
FISABIO
(98% Valencia region, 10.7% Spain)
Swedish Health Registers
(100% Sweden)
Scottish Prescribing Information System
(100% Scotland)
CPRD
(Aurum: 19.83 % UK, GOLD: 4.4% UK)
Name of database Country
Prescription/dispensings data
Danish Health Registers
Finnish Health Registers
SNDS
GePaRD
ARS Toscana
Caserta Regional Database
THIN

(prescription data)
PHARMO Database Network
Norwegian Health and Administrative Registers
SIDIAP
FISABIO
Swedish Health Registers
Scottish Prescribing Information System
CPRD
Name of database Country
Hospital data
Danish Health Registers
Finnish Health Registers
SNDS
GePaRD
ARS Toscana
Caserta Regional Database
THIN

(partial)
PHARMO Database Network
Norwegian Health and Administrative Registers
VID
SIDIAP
FISABIO
Swedish Health Registers
Scottish Prescribing Information System
CPRD
Name of database Country
Primary care data
Danish Health Registers
Finnish Health Registers

(since 2011)
SNDS
GePaRD
ARS Toscana
Caserta Regional Database
THIN
PHARMO Database Network
Norwegian Health and Administrative Registers
SIDIAP
FISABIO
Swedish Health Registers

(regional)
Scottish Prescribing Information System
CPRD
Name of database Country
Laboratory data
Danish Health Registers
Finnish Health Registers

(since 2014)
SNDS
GePaRD
ARS Toscana
Caserta Regional Database

(Lab test request available;
around 20% of the of the lab tests
results for
people residing in Caserta
are performed in
public healthcare structures
and can be traced)
THIN

(partial)
PHARMO Database Network
Norwegian Health and Administrative Registers

(Only positive tests fot notifiable infectious diseases)
SIDIAP
FISABIO
Swedish Health Registers

(regional)
Scottish Prescribing Information System
CPRD
Name of database Country
Cancer data
Danish Health Registers
Finnish Health Registers
SNDS
GePaRD
ARS Toscana
Caserta Regional Database
THIN

(partial)
PHARMO Database Network
Norwegian Health and Administrative Registers
SIDIAP
FISABIO
Swedish Health Registers
Scottish Prescribing Information System
CPRD
Name of database Country
Pregnancy data
Danish Health Registers
Finnish Health Registers
SNDS
GePaRD
ARS Toscana
Caserta Regional Database

(pregnant persons can be identified through birth registry - 2018)
THIN

(partial)
PHARMO Database Network
Norwegian Health and Administrative Registers
SIDIAP
FISABIO
Swedish Health Registers
Scottish Prescribing Information System
CPRD
Name of database Country
Emergency data
Danish Health Registers
Finnish Health Registers

(limited)
SNDS
GePaRD
ARS Toscana
Caserta Regional Database

(limited)
THIN
PHARMO Database Network
Norwegian Health and Administrative Registers
SIDIAP
FISABIO
Swedish Health Registers
Scottish Prescribing Information System
CPRD
Most relevant publication
Most relevant publication
Danish Health Registers
Danish HC system publication
Finnish Health Registers
Finnish HC registers publication
SNDS
French HC system publication-1
French HC system publication-2
GePaRD
GePaRD publication
ARS Toscana
Italy HC DBs publication-1
Italy HC DBs publication-2
Caserta Regional Database
Caserta study publication
THIN
PHARMO Database Network
PHARMO DB Network publication
Norwegian Health and Administrative Registers
Nordic Health Registry-Based Research publication
SIDIAP
FISABIO
VID Publication
Swedish Health Registers
Nordic Health Registry-Based Research publication
Scottish Prescribing Information System
PIS publication
CPRD
CPRD Aurum publication
ARS = Agenzia regionale di sanità; CPRD = Clinical Practice Research Datalink; EMR = Electronic medical records; FISABIO = Fundació per al Foment de la Investigació Sanitària i Biomèdica de la Comunitat Valenciana; GePaRD = German Pharmacoepidemiological Research Database; NIPH = Norwegian Institute of Public Health; SDU = Southern Denmark University; SIDIAP = Sistema d'Informació per al Desenvolupament de la Investigació en Atenció Primaria; SNDS = French National Healthcare System database; THIN = The Health Improvement Network; UNIMIB = University of Milano Bicocca; VID = The Valencia Health System Integrated Database

In March 2022, the SIGMA Consortium and VAC4EU formally joined forces and expressed their shared vision and mutual goal to continue collaborating, developing existing synergies, and sharing expertise and knowledge, information, and tools developed by the two networks for pharmacoepidemiology/real world evidence studies and activities.

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