The SIGMA Consortium is formed by a group of leading research institutions and Universities with extensive expertise and experience in the conduct of pharmacoepidemiologic and real-world evidence research:
| Country | Institution | Lead |
| Denmark | Aarhus University, Department of Clinical Epidemiology |  Prof. Vera Ehrenstein |
| Denmark | University of Southern Denmark, Department of Clinical Pharmacology and Pharmacy |  Prof. Jesper Hallas, FISPE |
| France | University of Bordeaux’s Bordeaux PharmacoEpi Platform |  Dr. Cecilé Droz |
| Germany | Leibniz-Institut für Präventionsforschung und Epidemiologie – BIPS GmbH |  Prof. Ulrike Haug |
| Italy | Agenzia Regionale di Sanità (ARS Toscana) |  Dr. Rosa Gini |
| Netherlands | PHARMO Institute for Drug Outcomes Research |  Prof. Ron Herings, FISPE |
| Netherlands | University Medical Centre Utrecht (UMCU) |  Prof. Miriam Sturkenboom, FISPE |
| Netherlands | Utrecht University Division of Pharmacoepidemiology & Clinical Pharmacology |  Prof. Olaf Klungel |
| Spain | Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol) |  Dr. Maria Giner |
| Spain/USA | RTI Health Solutions |  Dr. Susana Perez-Gutthann, FISPE |
| United Kingdom | University of Dundee |  Prof. Thomas MacDonald, FISPE |
The SIGMA consortium collaborates with the following research institutions:
| Country | Institution | Lead |
| Sweden | Karolinska Institute | Prof. Helle Kieler |
| Italy | University of Verona |  Dr. Gianluca Trifiró |
| Italy | UNIMIB |  Prof. Giampiero Mazzaglia |